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Ciprofloxacin

CHEMBL8 Phase 4 अनुमोदित Small molecule
Half-Life
4 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
331.3 g/mol
LogP
-1.1
Phase
4

A broad-spectrum fluoroquinolone, ciprofloxacin halts bacterial DNA replication by inhibiting the enzymes DNA gyrase and topoisomerase IV. It treats urinary and respiratory tract infections, typhoid fever, and certain gram-negative infections, and is stockpiled for anthrax prophylaxis. Marketed as Cipro and Ciloxan, it carries the formula C17H18FN3O3. Tendon rupture, peripheral neuropathy, and prolongation of the cardiac QT interval are recognized safety concerns that shape its use, and rising resistance has narrowed some of its former applications.

A broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication. It is used for a wide range of infections including urinary tract infections, respiratory infections, typhoid fever, and anthrax prophylaxis. Tendon rupture, peripheral neuropathy, and prolongation of the QT interval are important safety concerns.

आणविक भार

331.3460 g/mol

LogP

-1.10

TPSA

72.90 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

यूरोलॉजी संक्रामक रोग

दवा वर्ग

J — J - प्रणालीगत उपयोग हेतु एंटीइन्फेक्टिव

क्रिया का तंत्र

Inhibits bacterial DNA gyrase and topoisomerase IV.

Pharmacokinetics (PK)

Half-Life 4 hours

Pharmacodynamics (PD)

तंत्र

Inhibits bacterial DNA gyrase and topoisomerase IV.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H18FN3O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
घूर्णनीय बंधन

                        
3

                    

                    
                    
                    

                        
भारी परमाणु

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Ciprofloxacin + Ondansetron
                            
                        

                        
                        
Ciprofloxacin and ondansetron both prolong the QT interval; combined use raises the risk of torsades de pointes and sudden cardiac death.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Ciprofloxacin + Quetiapine
                            
                        

                        
                        
Ciprofloxacin and quetiapine both prolong the QT interval and ciprofloxacin also increases quetiapine exposure via CYP3A4 inhibition.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Ciprofloxacin + Levothyroxine
                            
                        

                        
                        
Ciprofloxacin can reduce levothyroxine absorption through complex formation and potential effects on gut motility and transport, risking under-replacement in hypothyroid patients on long courses.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Ciprofloxacin + Warfarin
                            
                        

                        
                        
Ciprofloxacin consistently enhances warfarin's anticoagulant effect, raising INR and increasing the risk of bleeding complications.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Ciprofloxacin + Azithromycin
                            
                        

                        
                        
Both azithromycin and ciprofloxacin prolong the QT interval; concurrent or overlapping use significantly increases torsades de pointes risk.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication. It is used for a wide range of infections including urinary tract infections, respiratory infections, typhoid fever, and anthrax prophylaxis. Tendon rupture, peripheral neuropathy, and prolongation of the QT interval are important safety concerns.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits bacterial DNA gyrase and topoisomerase IV.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Ciprofloxacin: Half-life: 4 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Ciprofloxacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            
            

                
                
                    ADME Journey →
                
                
                
            

            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amoxicillin
                            Small molecule
                        
                        
                        
                            Azithromycin
                            Small molecule
                        
                        
                        
                            Doxycycline
                            Small molecule
                        
                        
                        
                            Metronidazole
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL8.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2764.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.