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Metronidazole

CHEMBL137 Phase 4 अनुमोदित Small molecule
Half-Life
8 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
171.2 g/mol
LogP
—
Phase
4

Reductive activation inside anaerobic organisms converts metronidazole into cytotoxic free radicals that fragment microbial DNA, an activation step that requires the low-redox environment such organisms provide and that explains the drug's selectivity. Its spectrum spans both bacteria and protozoa, supporting use in infections of the digestive tract, the reproductive system and the skin. Warfarin is recorded as a major interaction, the anticoagulant effect being potentiated when the two are given together. An elimination half-life near eight hours accompanies its classification among antiinfectives for systemic use. The molecule is small, C6H9N3O3 at approximately 171.2 g/mol, and reached the final phase of clinical development.

This antibiotic and antiprotozoal drug kills bacteria and parasites by damaging their DNA. It is used to treat a wide range of infections including those of the digestive tract, reproductive system, and skin.

आणविक भार

171.1540 g/mol

LogP

0.00

TPSA

83.90 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

संक्रामक रोग

दवा वर्ग

J — J - प्रणालीगत उपयोग हेतु एंटीइन्फेक्टिव

Pharmacokinetics (PK)

Half-Life 8 hours

Pharmacodynamics (PD)

2D संरचना

SVG PNG

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SMILES

                    
Cc1ncc([N+](=O)[O-])n1CCO

                

                

                
                

                    
InChI

                    
InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H9N3O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
घूर्णनीय बंधन

                        
2

                    

                    
                    
                    

                        
भारी परमाणु

                        
12

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Metronidazole + Warfarin
                            
                        

                        
                        
Metronidazole markedly potentiates warfarin anticoagulation, leading to supratherapeutic INR levels and an elevated risk of serious bleeding.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
This antibiotic and antiprotozoal drug kills bacteria and parasites by damaging their DNA. It is used to treat a wide range of infections including those of the digestive tract, reproductive system, and skin.

                        

                    

                    

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Metronidazole: Half-life: 8 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Metronidazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amoxicillin
                            Small molecule
                        
                        
                        
                            Azithromycin
                            Small molecule
                        
                        
                        
                            Ciprofloxacin
                            Small molecule
                        
                        
                        
                            Doxycycline
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL137.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4173.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.