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Metronidazole

CHEMBL137 Phase 4 已批准 Small molecule
Half-Life
8 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
171.2 g/mol
LogP
—
Phase
4

This antibiotic and antiprotozoal drug kills bacteria and parasites by damaging their DNA. It is used to treat a wide range of infections including those of the digestive tract, reproductive system, and skin.

分子量

171.1540 g/mol

LogP

0.00

TPSA

83.90 Ų

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Glaucoma Cardiovascular Disease Age-Related Macular Degeneration Pain Management Ophthalmology Non-Small Cell Lung Cancer Asthma Chronic Obstructive Pulmonary Disease Immunology Parkinson's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Melanoma Oncology Inflammatory Bowel Disease Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Deep Vein Thrombosis / Pulmonary Embolism Obesity Lymphoma Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain Malaria HIV/AIDS Tuberculosis Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

药物分类

J — J - Antiinfectives for Systemic Use

作用机制

Forms cytotoxic free radicals that damage bacterial DNA.

Pharmacokinetics (PK)

Half-Life 8 hours

Pharmacodynamics (PD)

机制

Forms cytotoxic free radicals that damage bacterial DNA.

二维结构

SVG PNG

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SMILES

                    
Cc1ncc([N+](=O)[O-])n1CCO

                

                

                
                

                    
InChI

                    
InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H9N3O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
可旋转键数

                        
2

                    

                    
                    
                    

                        
重原子数

                        
12

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            CYP2D6 (Cytochrome P450 2D6)
                            Inhibitor
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Metronidazole + Warfarin
                            
                        

                        
                        
Metronidazole markedly potentiates warfarin anticoagulation, leading to supratherapeutic INR levels and an elevated risk of serious bleeding.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This antibiotic and antiprotozoal drug kills bacteria and parasites by damaging their DNA. It is used to treat a wide range of infections including those of the digestive tract, reproductive system, and skin.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Forms cytotoxic free radicals that damage bacterial DNA.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Metronidazole: Half-life: 8 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Metronidazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amoxicillin
                            Small molecule
                        
                        
                        
                            Azithromycin
                            Small molecule
                        
                        
                        
                            Ciprofloxacin
                            Small molecule
                        
                        
                        
                            Doxycycline
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL137.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4173.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.