Doxycycline
A broad-spectrum tetracycline antibiotic, doxycycline inhibits bacterial growth by binding the 30S ribosomal subunit and blocking protein synthesis. Its wide range of activity covers respiratory and skin infections as well as tick-borne diseases, and its anti-inflammatory properties extend its use to conditions such as rosacea and to malaria prevention. A tetracycline small molecule (C22H24N2O8) with a half-life of roughly 18 to 22 hours, it supports once- or twice-daily dosing and penetrates tissues well. Because it targets the bacterial ribosome rather than the structurally different human one, it acts selectively against microbes. That selectivity, combined with broad coverage, keeps it in wide clinical use. Doxycycline is an approved antibiotic employed across infectious and inflammatory indications.
A broad-spectrum tetracycline antibiotic used to treat bacterial infections including respiratory infections, skin infections, and tick-borne diseases. It also has anti-inflammatory properties and is used in conditions like rosacea and malaria prevention.
分子量
444.4350 g/mol
LogP
-0.70
TPSA
182.00 Ų
Lipinski 五规则
符合
治疗领域
药物分类
作用机制
Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.
二维结构
Cite this structure
Embed this structure
SMILES
C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.O
InChI
InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
Molecular Formula
C22H24N2O8
HBD / HBA
6 / 9
可旋转键数
2
重原子数
32
Doxycycline may slightly enhance the glucose-lowering effect of metformin by improving insulin sensitivity through anti-inflammatory mechanisms, occasionally causing mild hypoglycaemia.
Doxycycline has been investigated as a complementary agent in HER2-positive breast cancer; its anti-mitochondrial and anti-stem-cell properties may modestly enhance trastuzumab activity without clinically significant adverse pharmacokinetic interaction.
No clinically significant pharmacokinetic or pharmacodynamic interaction is established between doxycycline and finasteride; they are occasionally co-prescribed in patients with androgenetic alopecia and concomitant infections.
Doxycycline may enhance warfarin's anticoagulant effect, particularly in patients whose vitamin K intake is already limited.
Doxycycline is reported to modestly inhibit CYP3A4, potentially increasing amlodipine plasma levels; the clinical consequence is minor given amlodipine's wide therapeutic index.
Doxycycline may slightly raise atorvastatin plasma levels through weak inhibition of CYP3A4 and P-glycoprotein, though clinically significant myopathy from this combination is rarely reported.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A broad-spectrum tetracycline antibiotic used to treat bacterial infections including respiratory infections, skin infections, and tick-borne diseases. It also has anti-inflammatory properties and is used in conditions like rosacea and malaria prevention.
Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.
Key pharmacokinetic parameters for Doxycycline: Half-life: 18-22 hours.
Yes, Doxycycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200699. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54671203. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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