Doxycycline
A broad-spectrum tetracycline antibiotic, doxycycline inhibits bacterial growth by binding the 30S ribosomal subunit and blocking protein synthesis. Its wide range of activity covers respiratory and skin infections as well as tick-borne diseases, and its anti-inflammatory properties extend its use to conditions such as rosacea and to malaria prevention. A tetracycline small molecule (C22H24N2O8) with a half-life of roughly 18 to 22 hours, it supports once- or twice-daily dosing and penetrates tissues well. Because it targets the bacterial ribosome rather than the structurally different human one, it acts selectively against microbes. That selectivity, combined with broad coverage, keeps it in wide clinical use. Doxycycline is an approved antibiotic employed across infectious and inflammatory indications.
A broad-spectrum tetracycline antibiotic used to treat bacterial infections including respiratory infections, skin infections, and tick-borne diseases. It also has anti-inflammatory properties and is used in conditions like rosacea and malaria prevention.
Berat Molekul
444,4350 g/mol
LogP
-0,70
TPSA
182,00 Ų
Lipinski RO5
Lulus
Area Terapeutik
Kelas Obat
Mekanisme Kerja
Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.
Struktur 2D
Cite this structure
Embed this structure
SMILES
C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21.O
InChI
InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
Molecular Formula
C22H24N2O8
HBD / HBA
6 / 9
Ikatan yang Dapat Dirotasi
2
Atom Berat
32
Doxycycline may slightly enhance the glucose-lowering effect of metformin by improving insulin sensitivity through anti-inflammatory mechanisms, occasionally causing mild hypoglycaemia.
Doxycycline has been investigated as a complementary agent in HER2-positive breast cancer; its anti-mitochondrial and anti-stem-cell properties may modestly enhance trastuzumab activity without clinically significant adverse pharmacokinetic interaction.
No clinically significant pharmacokinetic or pharmacodynamic interaction is established between doxycycline and finasteride; they are occasionally co-prescribed in patients with androgenetic alopecia and concomitant infections.
Doxycycline may enhance warfarin's anticoagulant effect, particularly in patients whose vitamin K intake is already limited.
Doxycycline is reported to modestly inhibit CYP3A4, potentially increasing amlodipine plasma levels; the clinical consequence is minor given amlodipine's wide therapeutic index.
Doxycycline may slightly raise atorvastatin plasma levels through weak inhibition of CYP3A4 and P-glycoprotein, though clinically significant myopathy from this combination is rarely reported.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
A broad-spectrum tetracycline antibiotic used to treat bacterial infections including respiratory infections, skin infections, and tick-borne diseases. It also has anti-inflammatory properties and is used in conditions like rosacea and malaria prevention.
Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.
Key pharmacokinetic parameters for Doxycycline: Half-life: 18-22 hours.
Yes, Doxycycline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200699. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54671203. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="doxycycline"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/doxycycline/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/doxycycline/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/doxycycline/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="doxycycline"></drugfyi-drug>