Colchicine
An ancient plant-derived drug that disrupts microtubule formation in neutrophils, making it highly effective for treating and preventing gout attacks and pericarditis. At low doses it has been shown to reduce cardiovascular events in patients with coronary artery disease.
आणविक भार
399.4370 g/mol
LogP
1.00
TPSA
83.10 Ų
लिपिंस्की RO5
उत्तीर्ण
चिकित्सीय क्षेत्र
दवा वर्ग
क्रिया का तंत्र
Binds tubulin disrupting microtubule polymerization; anti-inflammatory.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds tubulin disrupting microtubule polymerization; anti-inflammatory.
2D संरचना
Cite this structure
Embed this structure
SMILES
COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
InChI
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
Molecular Formula
C22H25NO6
HBD / HBA
1 / 6
घूर्णनीय बंधन
5
भारी परमाणु
29
Concurrent use of colchicine and pravastatin carries a small theoretical risk of myopathy, as both drugs individually can cause muscle toxicity, though the combination is better tolerated than colchicine with …
Rosuvastatin and colchicine share BCRP transporter-mediated elimination; colchicine may weakly increase rosuvastatin exposure, and both carry myotoxic potential that could be additive.
Colchicine may increase bleeding risk when combined with warfarin; isolated case reports suggest possible INR elevation, though the mechanism is not well characterized.
Azithromycin inhibits P-glycoprotein and CYP3A4-mediated metabolism of colchicine, increasing colchicine plasma concentrations and the risk of colchicine toxicity, including neuromuscular and gastrointestinal toxicity.
No side effects recorded
Side effect data is not yet available for this drug.
अक्सर पूछे जाने वाले प्रश्न
An ancient plant-derived drug that disrupts microtubule formation in neutrophils, making it highly effective for treating and preventing gout attacks and pericarditis. At low doses it has been shown to reduce cardiovascular events in patients with coronary artery disease.
Binds tubulin disrupting microtubule polymerization; anti-inflammatory.
Key pharmacokinetic parameters for Colchicine: Half-life: 26-31 hours.
Yes, Colchicine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL107. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6167. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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