Methylprednisolone
A corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, including allergic reactions, asthma flares, rheumatoid arthritis, and multiple sclerosis relapses. It is available in oral, injectable, and topical forms.
आणविक भार
374.4710 g/mol
LogP
1.90
TPSA
94.80 Ų
लिपिंस्की RO5
उत्तीर्ण
चिकित्सीय क्षेत्र
दवा वर्ग
क्रिया का तंत्र
Intermediate-acting synthetic glucocorticoid.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Intermediate-acting synthetic glucocorticoid.
2D संरचना
Cite this structure
Embed this structure
SMILES
C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)CO)[C@@]2(C)C=CC(=O)C=C12
InChI
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
Molecular Formula
C22H30O5
HBD / HBA
3 / 5
घूर्णनीय बंधन
2
भारी परमाणु
27
Diltiazem inhibits CYP3A4-mediated methylprednisolone metabolism, increasing methylprednisolone exposure and the risk of steroid side effects including immunosuppression, hyperglycaemia, and hypertension.
Fluconazole inhibits CYP3A4-mediated metabolism of methylprednisolone, increasing its plasma levels and prolonging corticosteroid effects, raising the risk of Cushingoid features.
Methylprednisolone inhibits CYP3A4-mediated cyclosporine metabolism, raising cyclosporine levels; conversely, cyclosporine may increase methylprednisolone exposure — a bidirectional pharmacokinetic interaction.
No side effects recorded
Side effect data is not yet available for this drug.
अक्सर पूछे जाने वाले प्रश्न
A corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, including allergic reactions, asthma flares, rheumatoid arthritis, and multiple sclerosis relapses. It is available in oral, injectable, and topical forms.
Intermediate-acting synthetic glucocorticoid.
Key pharmacokinetic parameters for Methylprednisolone: Half-life: 18-36 hours.
Yes, Methylprednisolone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL650. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6741. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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