OATP1B3 (OATP1B3)
OATP1B3Organic Anion-Transporting Polypeptide 1B3 (gene: SLCO1B3), a hepatic uptake transporter with overlapping substrate specificity to OATP1B1 but distinct tissue expression and substrate preferences. Mediates hepatic uptake of statins, methotrexate, paclitaxel, docetaxel, and endogenous compounds like cholecystokinin and bilirubin glucuronides. FDA-recommended for evaluation in clinical DDI studies alongside OATP1B1.
उदाहरण
- Mycophenolate glucuronide enterohepatic recirculation via OATP1B3
- Docetaxel hepatic uptake and clearance
- Rifampin inhibition raising rosuvastatin AUC
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Organic Anion-Transporting Polypeptide 1B3 (gene: SLCO1B3), a hepatic uptake transporter with overlapping substrate specificity to OATP1B1 but distinct tissue expression and substrate preferences. Mediates hepatic uptake of statins, methotrexate, paclitaxel, …