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Receptor Desensitization

Pharmacodynamics

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.

उदाहरण

  • Beta-2 agonist tachyphylaxis
  • Opioid tolerance
  • Nicotinic receptor desensitization

क्या आप जानते हैं?

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.