Receptor Upregulation
An increase in the number or sensitivity of receptors on the cell surface, usually in response to chronic antagonist exposure or reduced agonist stimulation. Upregulation is a compensatory mechanism that can lead to rebound effects upon abrupt drug withdrawal. It represents an important consideration for tapering schedules.
उदाहरण
- Beta-receptor upregulation after chronic propranolol — rebound tachycardia on withdrawal
- D2 receptor upregulation after long-term antipsychotic use — tardive dyskinesia risk
- GABA-A receptor upregulation concept in benzodiazepine withdrawal seizures
क्या आप जानते हैं?
An increase in the number or sensitivity of receptors on the cell surface, usually in response to chronic antagonist exposure or reduced agonist stimulation. Upregulation is a compensatory mechanism that …