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Dapagliflozin

CHEMBL429910 Phase 4 Disetujui Small molecule
Half-Life
12.9 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
408.9 g/mol
LogP
2.3
Phase
4

An SGLT2 inhibitor that lowers blood sugar by blocking glucose reabsorption in the kidney, causing excess glucose to be excreted in urine, and has additional benefits for heart failure and chronic kidney disease regardless of diabetes status. It also promotes modest weight loss and blood pressure reduction.

Berat Molekul

408,8730 g/mol

LogP

2,30

TPSA

99,40 Ų

Lipinski RO5

Lulus

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Benign Prostatic Hyperplasia Cardiovascular Disease Non-Small Cell Lung Cancer Schizophrenia Inflammatory Bowel Disease Systemic Lupus Erythematosus Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer

Kelas Obat

A — A - Alimentary Tract and Metabolism

Mekanisme Kerja

Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

Pharmacokinetics (PK)

Half-Life 12.9 hours

Pharmacodynamics (PD)

Mekanisme

Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

Struktur 2D

SVG PNG

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SMILES

                    
CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H25ClO6

                    

                    
                    

                        
HBD / HBA

                        
4 / 6

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
6

                    

                    
                    
                    

                        
Atom Berat

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
An SGLT2 inhibitor that lowers blood sugar by blocking glucose reabsorption in the kidney, causing excess glucose to be excreted in urine, and has additional benefits for heart failure and chronic kidney disease regardless of diabetes status. It also promotes modest weight loss and blood pressure reduction.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Dapagliflozin: Half-life: 12.9 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Dapagliflozin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Metformin
                            Small molecule
                        
                        
                        
                            Omeprazole
                            Small molecule
                        
                        
                        
                            Pantoprazole
                            Small molecule
                        
                        
                        
                            Lansoprazole
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL429910.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9887712.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.