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Desvenlafaxine

CHEMBL1118 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
263.4 g/mol
LogP
2.6
Phase
4

An SNRI antidepressant and active metabolite of venlafaxine that inhibits the reuptake of both serotonin and norepinephrine, used for major depressive disorder and also investigated for vasomotor symptoms of menopause. It has a simpler metabolism than venlafaxine due to minimal CYP2D6 involvement.

Berat Molekul

263,3700 g/mol

LogP

2,60

TPSA

43,70 Ų

Lipinski RO5

Lulus

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Pain Management Non-Small Cell Lung Cancer Migraine Bipolar Disorder Generalized Anxiety Disorder Type 2 Diabetes Major Depressive Disorder Breast Cancer Chronic Pain Cardiovascular Disease Prostate Cancer Colorectal Cancer

Mekanisme Kerja

Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H25NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
4

                    

                    
                    
                    

                        
Atom Berat

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
An SNRI antidepressant and active metabolite of venlafaxine that inhibits the reuptake of both serotonin and norepinephrine, used for major depressive disorder and also investigated for vasomotor symptoms of menopause. It has a simpler metabolism than venlafaxine due to minimal CYP2D6 involvement.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Desvenlafaxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1118.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 125017.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.