Desvenlafaxine
An SNRI antidepressant and active metabolite of venlafaxine that inhibits the reuptake of both serotonin and norepinephrine, used for major depressive disorder and also investigated for vasomotor symptoms of menopause. It has a simpler metabolism than venlafaxine due to minimal CYP2D6 involvement.
Peso Molecular
263,3700 g/mol
LogP
2,60
TPSA
43,70 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1
InChI
InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
Molecular Formula
C16H25NO2
HBD / HBA
2 / 3
Ligações Rotacionáveis
4
Átomos Pesados
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An SNRI antidepressant and active metabolite of venlafaxine that inhibits the reuptake of both serotonin and norepinephrine, used for major depressive disorder and also investigated for vasomotor symptoms of menopause. It has a simpler metabolism than venlafaxine due to minimal CYP2D6 involvement.
Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.
Yes, Desvenlafaxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1118. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 125017. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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