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Erlotinib

CHEMBL553 Phase 4 Disetujui Small molecule
Half-Life
36 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
393.4 g/mol
LogP
3.3
Phase
4

This oral targeted therapy blocks the EGFR protein that drives the growth of cancer cells in certain lung cancers and pancreatic cancers. It is most effective in patients whose tumors have specific EGFR mutations.

Berat Molekul

393,4380 g/mol

LogP

3,30

TPSA

74,70 Ų

Lipinski RO5

Lulus

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Age-Related Macular Degeneration Respiratory Disease Pain Management Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Infectious Disease Melanoma Gastroesophageal Reflux Disease Inflammatory Bowel Disease Psoriasis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Lymphoma Breast Cancer Chronic Pain Hepatitis C Prostate Cancer Colorectal Cancer Leukemia

Kelas Obat

L — L - Antineoplastic and Immunomodulating Agents

Mekanisme Kerja

Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

Pharmacokinetics (PK)

Half-Life 36 hours

Pharmacodynamics (PD)

Mekanisme

Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

Struktur 2D

SVG PNG

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SMILES

                    
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H23N3O4

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
11

                    

                    
                    
                    

                        
Atom Berat

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
This oral targeted therapy blocks the EGFR protein that drives the growth of cancer cells in certain lung cancers and pancreatic cancers. It is most effective in patients whose tumors have specific EGFR mutations.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Erlotinib: Half-life: 36 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Erlotinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Methotrexate
                            Small molecule
                        
                        
                        
                            Tamoxifen
                            Small molecule
                        
                        
                        
                            Cyclosporine
                            Protein
                        
                        
                        
                            Tacrolimus
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL553.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 176870.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.