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Erlotinib

CHEMBL553 Phase 4 已批准 Small molecule
Half-Life
36 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
393.4 g/mol
LogP
3.3
Phase
4

This oral targeted therapy blocks the EGFR protein that drives the growth of cancer cells in certain lung cancers and pancreatic cancers. It is most effective in patients whose tumors have specific EGFR mutations.

分子量

393.4380 g/mol

LogP

3.30

TPSA

74.70 Ų

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Age-Related Macular Degeneration Respiratory Disease Pain Management Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Infectious Disease Melanoma Gastroesophageal Reflux Disease Inflammatory Bowel Disease Psoriasis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Lymphoma Breast Cancer Chronic Pain Hepatitis C Prostate Cancer Colorectal Cancer Leukemia

药物分类

L — L - Antineoplastic and Immunomodulating Agents

作用机制

Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

Pharmacokinetics (PK)

Half-Life 36 hours

Pharmacodynamics (PD)

机制

Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H23N3O4

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
可旋转键数

                        
11

                    

                    
                    
                    

                        
重原子数

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This oral targeted therapy blocks the EGFR protein that drives the growth of cancer cells in certain lung cancers and pancreatic cancers. It is most effective in patients whose tumors have specific EGFR mutations.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Erlotinib: Half-life: 36 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Erlotinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
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{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL553.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 176870.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.