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Nitroglycerin

CHEMBL730 Phase 4 Disetujui Small molecule
Half-Life
1-4 minutes
Bioavailability
—
Protein Binding
—
Molecular Weight
227.1 g/mol
LogP
1.6
Phase
4

Donation of nitric oxide is the mechanism by which nitroglycerin dilates veins and arteries, relieving the chest pain that arises when myocardial blood supply falls short of demand. Venodilation reduces preload and therefore the work the heart must perform, which relieves ischaemic pain rather than removing the obstruction causing it. Onset is rapid and the effect brief: the plasma half-life is measured in one to four minutes, which is why the drug suits acute relief. Sildenafil is recorded as a major interaction, since both act on the same cyclic GMP pathway and combined use risks profound hypotension. The compound is C3H5N3O9, about 227.1 g/mol.

A fast-acting medication that widens blood vessels to quickly relieve chest pain caused by insufficient blood supply to the heart.

Berat Molekul

227,0870 g/mol

LogP

1,60

TPSA

165,00 Ų

Lipinski RO5

Lulus

Kelas Obat

C — C - Cardiovascular System

Mekanisme Kerja

Nitric oxide donor causing venous and arterial vasodilation.

Pharmacokinetics (PK)

Half-Life 1-4 minutes

Pharmacodynamics (PD)

Mekanisme

Nitric oxide donor causing venous and arterial vasodilation.

Struktur 2D

SVG PNG

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SMILES

                    
O=[N+]([O-])OCC(CO[N+](=O)[O-])O[N+](=O)[O-]

                

                

                
                

                    
InChI

                    
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C3H5N3O9

                    

                    
                    

                        
HBD / HBA

                        
- / 9

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
5

                    

                    
                    
                    

                        
Atom Berat

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Nitroglycerin + Sildenafil
                            
                        

                        
                        
Combining sildenafil with nitrates causes profound, potentially fatal hypotension; this combination is absolutely contraindicated.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
A fast-acting medication that widens blood vessels to quickly relieve chest pain caused by insufficient blood supply to the heart.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Nitric oxide donor causing venous and arterial vasodilation.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Nitroglycerin: Half-life: 1-4 minutes.

                        

                    

                    

                    

                        
                        

                            
Yes, Nitroglycerin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Lisinopril
                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL730.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4510.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.