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Nitroglycerin

CHEMBL730 Phase 4 Approved Small molecule
Half-Life
1-4 minutes
Bioavailability
—
Protein Binding
—
Molecular Weight
227.1 g/mol
LogP
1.6
Phase
4

A fast-acting medication that widens blood vessels to quickly relieve chest pain caused by insufficient blood supply to the heart.

Molecular Weight

227.0870 g/mol

LogP

1.60

TPSA

165.00 Ų

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Cardiovascular Disease Chronic Kidney Disease Chronic Obstructive Pulmonary Disease Chronic Pain Colorectal Cancer Glaucoma Heart Failure Hyperlipidemia Hypertension Migraine Non-Small Cell Lung Cancer Osteoporosis Ovarian Cancer Pain Management Pancreatic Cancer Prostate Cancer Respiratory Disease Rheumatoid Arthritis Schizophrenia Stroke Systemic Lupus Erythematosus Thyroid Cancer Type 2 Diabetes

Drug Classes

C — C - Cardiovascular System

Mechanism of Action

Nitric oxide donor causing venous and arterial vasodilation.

Pharmacokinetics (PK)

Half-Life 1-4 minutes

Pharmacodynamics (PD)

Mechanism

Nitric oxide donor causing venous and arterial vasodilation.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=[N+]([O-])OCC(CO[N+](=O)[O-])O[N+](=O)[O-]

                

                

                
                

                    
InChI

                    
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C3H5N3O9

                    

                    
                    

                        
HBD / HBA

                        
- / 9

                    

                    
                    

                        
Rotatable Bonds

                        
5

                    

                    
                    
                    

                        
Heavy Atoms

                        
15

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            PDE5A (Phosphodiesterase 5)
                            Other
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Nitroglycerin + Sildenafil
                            
                        

                        
                        
Combining sildenafil with nitrates causes profound, potentially fatal hypotension; this combination is absolutely contraindicated.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
A fast-acting medication that widens blood vessels to quickly relieve chest pain caused by insufficient blood supply to the heart.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Nitric oxide donor causing venous and arterial vasodilation.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Nitroglycerin: Half-life: 1-4 minutes.

                        

                    

                    

                    

                        
                        

                            
Yes, Nitroglycerin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Atenolol
                            Small molecule
                        
                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Bisoprolol
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL730.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4510.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.