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Nitroglycerin

CHEMBL730 Phase 4 Aprovado Small molecule
Half-Life
1-4 minutes
Bioavailability
—
Protein Binding
—
Molecular Weight
227.1 g/mol
LogP
1.6
Phase
4

A fast-acting medication that widens blood vessels to quickly relieve chest pain caused by insufficient blood supply to the heart.

Peso Molecular

227,0870 g/mol

LogP

1,60

TPSA

165,00 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Cardiovascular Disease Respiratory Disease Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Osteoporosis Chronic Obstructive Pulmonary Disease Migraine Schizophrenia Systemic Lupus Erythematosus Chronic Kidney Disease Stroke Hyperlipidemia Type 2 Diabetes Hypertension Breast Cancer Chronic Pain Heart Failure Prostate Cancer Colorectal Cancer

Classes de Medicamentos

C — C - Cardiovascular System

Mecanismo de Ação

Nitric oxide donor causing venous and arterial vasodilation.

Pharmacokinetics (PK)

Half-Life 1-4 minutes

Pharmacodynamics (PD)

Mecanismo

Nitric oxide donor causing venous and arterial vasodilation.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=[N+]([O-])OCC(CO[N+](=O)[O-])O[N+](=O)[O-]

                

                

                
                

                    
InChI

                    
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C3H5N3O9

                    

                    
                    

                        
HBD / HBA

                        
- / 9

                    

                    
                    

                        
Ligações Rotacionáveis

                        
5

                    

                    
                    
                    

                        
Átomos Pesados

                        
15

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            PDE5A (Phosphodiesterase 5)
                            Other
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Nitroglycerin + Sildenafil
                            
                        

                        
                        
Combining sildenafil with nitrates causes profound, potentially fatal hypotension; this combination is absolutely contraindicated.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
A fast-acting medication that widens blood vessels to quickly relieve chest pain caused by insufficient blood supply to the heart.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Nitric oxide donor causing venous and arterial vasodilation.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Nitroglycerin: Half-life: 1-4 minutes.

                        

                    

                    

                    

                        
                        

                            
Yes, Nitroglycerin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Lisinopril
                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL730.
                Open-access bioactivity database.
            
        
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                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4510.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.