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Suprofen

CHEMBL956 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
260.3 g/mol
LogP
3.3
Phase
4

Suprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, formerly used systemically for pain and inflammation and now used as a topical ophthalmic NSAID to prevent surgically induced miosis during cataract surgery and relieve postoperative ocular inflammation. It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis in the anterior chamber that mediates intraoperative pupillary constriction. Systemic suprofen was withdrawn due to flank pain syndrome.

Berat Molekul

260,3100 g/mol

LogP

3,30

TPSA

82,60 Ų

Lipinski RO5

Lulus

Mekanisme Kerja

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Struktur 2D

SVG PNG

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SMILES

                    
CC(C(=O)O)c1ccc(C(=O)c2cccs2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H12O3S

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
4

                    

                    
                    
                    

                        
Atom Berat

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
Suprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, formerly used systemically for pain and inflammation and now used as a topical ophthalmic NSAID to prevent surgically induced miosis during cataract surgery and relieve postoperative ocular inflammation. It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis in the anterior chamber that mediates intraoperative pupillary constriction. Systemic suprofen was withdrawn due to flank pain syndrome.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Suprofen is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL956.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5359.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.