Suprofen
Suprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, formerly used systemically for pain and inflammation and now used as a topical ophthalmic NSAID to prevent surgically induced miosis during cataract surgery and relieve postoperative ocular inflammation. It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis in the anterior chamber that mediates intraoperative pupillary constriction. Systemic suprofen was withdrawn due to flank pain syndrome.
Moleküler Ağırlık
260,3100 g/mol
LogP
3,30
TPSA
82,60 Ų
Lipinski RO5
Geçer
Etki Mekanizması
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D Yapı
Cite this structure
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SMILES
CC(C(=O)O)c1ccc(C(=O)c2cccs2)cc1
InChI
InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
Molecular Formula
C14H12O3S
HBD / HBA
1 / 4
Döndürülebilir Bağlar
4
Ağır Atomlar
18
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Suprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, formerly used systemically for pain and inflammation and now used as a topical ophthalmic NSAID to prevent surgically induced miosis during cataract surgery and relieve postoperative ocular inflammation. It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis in the anterior chamber that mediates intraoperative pupillary constriction. Systemic suprofen was withdrawn due to flank pain syndrome.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Suprofen is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL956. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5359. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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