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Valproate Sodium

CHEMBL433 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
166.2 g/mol
LogP
—
Phase
4

Valproate sodium (sodium valproate) is the sodium salt of valproic acid, a broad-spectrum antiepileptic agent that enhances GABA-ergic neurotransmission, inhibits voltage-gated sodium channels, and blocks T-type calcium channels to stabilize neuronal membranes and reduce seizure activity. It is used for epilepsy (multiple seizure types), bipolar disorder (mood stabilization), and migraine prophylaxis. Its histone deacetylase inhibitor activity has led to investigation as an epigenetic modifier in cancer.

Berat Molekul

166,1900 g/mol

TPSA

40,10 Ų

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Non-Small Cell Lung Cancer Asthma Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Melanoma Stroke Deep Vein Thrombosis / Pulmonary Embolism Lymphoma Hypertension Major Depressive Disorder Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Mekanisme Kerja

Enhances GABA transmission and blocks sodium/calcium channels.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Enhances GABA transmission and blocks sodium/calcium channels.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCC(CCC)C(=O)[O-].[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H15NaO2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
5

                    

                    
                    
                    

                        
Atom Berat

                        
11

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
Valproate sodium (sodium valproate) is the sodium salt of valproic acid, a broad-spectrum antiepileptic agent that enhances GABA-ergic neurotransmission, inhibits voltage-gated sodium channels, and blocks T-type calcium channels to stabilize neuronal membranes and reduce seizure activity. It is used for epilepsy (multiple seizure types), bipolar disorder (mood stabilization), and migraine prophylaxis. Its histone deacetylase inhibitor activity has led to investigation as an epigenetic modifier in cancer.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Enhances GABA transmission and blocks sodium/calcium channels.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Valproate Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL433.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 16760703.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.