Velpatasvir
Velpatasvir is a pan-genotypic NS5A inhibitor that blocks the nonstructural protein 5A of hepatitis C virus (HCV), which is essential for viral RNA replication and virion assembly. It is used in combination with sofosbuvir (Epclusa) or sofosbuvir and voxilaprevir (Vosevi) for the treatment of chronic HCV infection across all six major genotypes. Its pan-genotypic activity simplifies treatment by eliminating the need for genotype testing before initiating therapy.
Berat Molekul
883,0000 g/mol
LogP
6,20
TPSA
193,00 Ų
Lipinski RO5
Gagal
Area Terapeutik
Mekanisme Kerja
Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.
Struktur 2D
Cite this structure
Embed this structure
SMILES
COC[C@H]1C[C@@H](c2nc(-c3ccc4c(c3)COc3cc5c(ccc6nc([C@@H]7CC[C@H](C)N7C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c65)cc3-4)c[nH]2)N(C(=O)[C@H](NC(=O)OC)c2ccccc2)C1
InChI
InChI=1S/C49H54N8O8/c1-26(2)41(54-48(60)63-5)47(59)57-27(3)12-17-38(57)45-51-36-16-14-30-20-35-33-15-13-31(19-32(33)25-65-40(35)21-34(30)43(36)53-45)37-22-50-44(52-37)39-18-28(24-62-4)23-56(39)46(58)42(55-49(61)64-6)29-10-8-7-9-11-29/h7-11,13-16,19-22,26-28,38-39,41-42H,12,17-18,23-25H2,1-6H3,(H,50,52)(H,51,53)(H,54,60)(H,55,61)/t27-,28-,38-,39-,41-,42+/m0/s1
Molecular Formula
C49H54N8O8
HBD / HBA
4 / 10
Ikatan yang Dapat Dirotasi
13
Atom Berat
65
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
Velpatasvir is a pan-genotypic NS5A inhibitor that blocks the nonstructural protein 5A of hepatitis C virus (HCV), which is essential for viral RNA replication and virion assembly. It is used in combination with sofosbuvir (Epclusa) or sofosbuvir and voxilaprevir (Vosevi) for the treatment of chronic HCV infection across all six major genotypes. Its pan-genotypic activity simplifies treatment by eliminating the need for genotype testing before initiating therapy.
Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.
Yes, Velpatasvir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3545062. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 67683363. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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