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Velpatasvir

CHEMBL3545062 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
883.0 g/mol
LogP
6.2
Phase
4

Velpatasvir is a pan-genotypic NS5A inhibitor that blocks the nonstructural protein 5A of hepatitis C virus (HCV), which is essential for viral RNA replication and virion assembly. It is used in combination with sofosbuvir (Epclusa) or sofosbuvir and voxilaprevir (Vosevi) for the treatment of chronic HCV infection across all six major genotypes. Its pan-genotypic activity simplifies treatment by eliminating the need for genotype testing before initiating therapy.

Khối lượng phân tử

883,0000 g/mol

LogP

6,20

TPSA

193,00 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

Non-Alcoholic Fatty Liver Disease Lymphoma HIV/AIDS Hepatitis C Heart Failure Cardiovascular Disease

Cơ chế tác dụng

Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COC[C@H]1C[C@@H](c2nc(-c3ccc4c(c3)COc3cc5c(ccc6nc([C@@H]7CC[C@H](C)N7C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c65)cc3-4)c[nH]2)N(C(=O)[C@H](NC(=O)OC)c2ccccc2)C1

                

                

                
                

                    
InChI

                    
InChI=1S/C49H54N8O8/c1-26(2)41(54-48(60)63-5)47(59)57-27(3)12-17-38(57)45-51-36-16-14-30-20-35-33-15-13-31(19-32(33)25-65-40(35)21-34(30)43(36)53-45)37-22-50-44(52-37)39-18-28(24-62-4)23-56(39)46(58)42(55-49(61)64-6)29-10-8-7-9-11-29/h7-11,13-16,19-22,26-28,38-39,41-42H,12,17-18,23-25H2,1-6H3,(H,50,52)(H,51,53)(H,54,60)(H,55,61)/t27-,28-,38-,39-,41-,42+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C49H54N8O8

                    

                    
                    

                        
HBD / HBA

                        
4 / 10

                    

                    
                    

                        
Liên kết có thể quay

                        
13

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
65

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Velpatasvir is a pan-genotypic NS5A inhibitor that blocks the nonstructural protein 5A of hepatitis C virus (HCV), which is essential for viral RNA replication and virion assembly. It is used in combination with sofosbuvir (Epclusa) or sofosbuvir and voxilaprevir (Vosevi) for the treatment of chronic HCV infection across all six major genotypes. Its pan-genotypic activity simplifies treatment by eliminating the need for genotype testing before initiating therapy.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the NS5A protein of hepatitis C virus, disrupting viral RNA replication and virion assembly.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Velpatasvir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3545062.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 67683363.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.