Therapeutic Index (TI)

Pharmacodynamics

The ratio of the toxic dose to the therapeutic dose (TD50/ED50 or LD50/ED50). A narrow therapeutic index means small dose changes can cause toxicity or loss of efficacy, requiring close monitoring.

Contoh

Lithium (NTI drug)
Warfarin (NTI drug)
Digoxin (NTI drug)

Tahukah Anda?

The ratio of the toxic dose to the therapeutic dose (TD50/ED50 or LD50/ED50). A narrow therapeutic index means small dose changes can cause toxicity or loss of efficacy, requiring close …