Moderate
Established
Deskripsi
Lansoprazole, like omeprazole, inhibits CYP2C19 and reduces clopidogrel's antiplatelet efficacy, potentially increasing cardiovascular event risk.
Mekanisme
Lansoprazole inhibits CYP2C19, reducing the formation of clopidogrel's active thiol metabolite and impairing P2Y12 receptor blockade.
Signifikansi Klinis
FDA and EMA communications note reduced platelet inhibition; pantoprazole is preferred when gastroprotection is needed.
Penatalaksanaan
Switch to pantoprazole if PPI is needed in clopidogrel-treated patients; if lansoprazole must be used, monitor for cardiovascular events.