Alogliptin
A DPP-4 inhibitor that enhances the body's natural incretin hormones to stimulate insulin secretion and reduce glucagon release in response to meals, lowering blood sugar in adults with type 2 diabetes. It has cardiovascular safety data showing it does not increase the risk of heart failure.
分子量
339.4000 g/mol
LogP
0.60
TPSA
93.70 Ų
リピンスキーの五則
適合
治療領域
作用機序
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.
2D構造
Cite this structure
Embed this structure
SMILES
Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O
InChI
InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
Molecular Formula
C18H21N5O2
HBD / HBA
1 / 5
回転可能結合数
3
重原子数
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A DPP-4 inhibitor that enhances the body's natural incretin hormones to stimulate insulin secretion and reduce glucagon release in response to meals, lowering blood sugar in adults with type 2 diabetes. It has cardiovascular safety data showing it does not increase the risk of heart failure.
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.
Yes, Alogliptin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL376359. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11450633. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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