Chlormerodrin

CHEMBL2110562 Phase 4 承認済み Small molecule
Half-Life
Bioavailability
Protein Binding
Molecular Weight
367.2 g/mol
LogP
Phase
4

An organomercury compound that was used historically as a diuretic and in nuclear medicine as a radiotracer for renal scintigraphy before safer alternatives became available. Its use has been entirely discontinued due to mercury toxicity risks. It represents an important chapter in the historical evolution of diuretics and medical imaging.

分子量

367.2000 g/mol

TPSA

64.40 Ų

作用機序

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

2D構造

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SMILES

COC(CNC(=O)N)C[Hg]Cl

InChI

InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1

Molecular Formula

C5H11ClHgN2O2

HBD / HBA

2 / 2

回転可能結合数

4

重原子数

11

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

よくある質問

An organomercury compound that was used historically as a diuretic and in nuclear medicine as a radiotracer for renal scintigraphy before safer alternatives became available. Its use has been entirely discontinued due to mercury toxicity risks. It represents an important chapter in the historical evolution of diuretics and medical imaging.

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Yes, Chlormerodrin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2110562. Open-access bioactivity database.
  • PubChem — National Center for Biotechnology Information (NCBI). CID 25210. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

医学的免責事項

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.