Chlormerodrin
An organomercury compound that was used historically as a diuretic and in nuclear medicine as a radiotracer for renal scintigraphy before safer alternatives became available. Its use has been entirely discontinued due to mercury toxicity risks. It represents an important chapter in the historical evolution of diuretics and medical imaging.
Molecular Weight
367.2000 g/mol
TPSA
64.40 Ų
Mechanism of Action
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
2D Structure
Cite this structure
Embed this structure
SMILES
COC(CNC(=O)N)C[Hg]Cl
InChI
InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1
Molecular Formula
C5H11ClHgN2O2
HBD / HBA
2 / 2
Rotatable Bonds
4
Heavy Atoms
11
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
An organomercury compound that was used historically as a diuretic and in nuclear medicine as a radiotracer for renal scintigraphy before safer alternatives became available. Its use has been entirely discontinued due to mercury toxicity risks. It represents an important chapter in the historical evolution of diuretics and medical imaging.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Chlormerodrin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2110562. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25210. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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