Cyclizine
An antihistamine with antiemetic and anticholinergic properties used to prevent and treat nausea, vomiting, and motion sickness. It acts centrally in the vomiting center of the brain and is used perioperatively and for vertigo.
分子量
266.4000 g/mol
LogP
3.60
TPSA
6.50 Ų
リピンスキーの五則
適合
治療領域
作用機序
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D構造
Cite this structure
Embed this structure
SMILES
CN1CCN(C(c2ccccc2)c2ccccc2)CC1
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
Molecular Formula
C18H22N2
HBD / HBA
- / 2
回転可能結合数
3
重原子数
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
An antihistamine with antiemetic and anticholinergic properties used to prevent and treat nausea, vomiting, and motion sickness. It acts centrally in the vomiting center of the brain and is used perioperatively and for vertigo.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Cyclizine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL648. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6726. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="cyclizine"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/cyclizine/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/cyclizine/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/cyclizine/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="cyclizine"></drugfyi-drug>