Cyclizine
An antihistamine with antiemetic and anticholinergic properties used to prevent and treat nausea, vomiting, and motion sickness. It acts centrally in the vomiting center of the brain and is used perioperatively and for vertigo.
Peso Molecular
266,4000 g/mol
LogP
3,60
TPSA
6,50 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Estrutura 2D
Cite this structure
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SMILES
CN1CCN(C(c2ccccc2)c2ccccc2)CC1
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
Molecular Formula
C18H22N2
HBD / HBA
- / 2
Ligações Rotacionáveis
3
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An antihistamine with antiemetic and anticholinergic properties used to prevent and treat nausea, vomiting, and motion sickness. It acts centrally in the vomiting center of the brain and is used perioperatively and for vertigo.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Cyclizine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL648. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6726. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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