Diclofenac
A widely used NSAID that inhibits both COX-1 and COX-2 enzymes to reduce prostaglandin synthesis, providing anti-inflammatory, analgesic, and antipyretic effects for conditions including arthritis, acute pain, and dysmenorrhea. It is available in oral, topical, and injectable formulations.
分子量
296.1000 g/mol
LogP
4.40
TPSA
49.30 Ų
リピンスキーの五則
適合
治療領域
作用機序
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
2D構造
Cite this structure
Embed this structure
SMILES
O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl
InChI
InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
Molecular Formula
C14H11Cl2NO2
HBD / HBA
2 / 3
回転可能結合数
4
重原子数
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A widely used NSAID that inhibits both COX-1 and COX-2 enzymes to reduce prostaglandin synthesis, providing anti-inflammatory, analgesic, and antipyretic effects for conditions including arthritis, acute pain, and dysmenorrhea. It is available in oral, topical, and injectable formulations.
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Yes, Diclofenac is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL139. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3033. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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