Lopinavir
An HIV protease inhibitor used exclusively in combination with ritonavir (as Kaletra) to boost its blood levels and treat HIV infection. The lopinavir-ritonavir combination is a cornerstone of antiretroviral therapy for both adults and children.
分子量
628.8000 g/mol
LogP
5.90
TPSA
120.00 Ų
リピンスキーの五則
不適合
治療領域
作用機序
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
2D構造
Cite this structure
Embed this structure
SMILES
Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O
InChI
InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
Molecular Formula
C37H48N4O5
HBD / HBA
4 / 5
回転可能結合数
15
重原子数
46
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
An HIV protease inhibitor used exclusively in combination with ritonavir (as Kaletra) to boost its blood levels and treat HIV infection. The lopinavir-ritonavir combination is a cornerstone of antiretroviral therapy for both adults and children.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Lopinavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL729. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 92727. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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