Lopinavir
An HIV protease inhibitor used exclusively in combination with ritonavir (as Kaletra) to boost its blood levels and treat HIV infection. The lopinavir-ritonavir combination is a cornerstone of antiretroviral therapy for both adults and children.
Molecular Weight
628.8000 g/mol
LogP
5.90
TPSA
120.00 Ų
Lipinski RO5
Fail
Therapeutic Areas
Mechanism of Action
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
2D Structure
Cite this structure
Embed this structure
SMILES
Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O
InChI
InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
Molecular Formula
C37H48N4O5
HBD / HBA
4 / 5
Rotatable Bonds
15
Heavy Atoms
46
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
An HIV protease inhibitor used exclusively in combination with ritonavir (as Kaletra) to boost its blood levels and treat HIV infection. The lopinavir-ritonavir combination is a cornerstone of antiretroviral therapy for both adults and children.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Lopinavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL729. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 92727. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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