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Prasterone

CHEMBL90593 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
288.4 g/mol
LogP
3.2
Phase
4

Prasterone (dehydroepiandrosterone, DHEA) is an endogenous steroid hormone and neurosteroid precursor that is peripherally converted to androgens and estrogens in target tissues, and also acts as a GABA receptor antagonist and NMDA receptor agonist. It is approved for the treatment of moderate-to-severe dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is under investigation for various other conditions.

分子量

288.4000 g/mol

LogP

3.20

TPSA

37.30 Ų

リピンスキーの五則

適合

治療領域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Cardiovascular Disease Non-Small Cell Lung Cancer Osteoporosis Asthma Chronic Obstructive Pulmonary Disease Psoriasis Systemic Lupus Erythematosus Multiple Sclerosis Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Malaria Prostate Cancer Colorectal Cancer

作用機序

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

                

                

                
                

                    
InChI

                    
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H28O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
回転可能結合数

                        
0

                    

                    
                    
                    

                        
重原子数

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Prasterone (dehydroepiandrosterone, DHEA) is an endogenous steroid hormone and neurosteroid precursor that is peripherally converted to androgens and estrogens in target tissues, and also acts as a GABA receptor antagonist and NMDA receptor agonist. It is approved for the treatment of moderate-to-severe dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is under investigation for various other conditions.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Prasterone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL90593.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5881.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.