Prasterone
Prasterone (dehydroepiandrosterone, DHEA) is an endogenous steroid hormone and neurosteroid precursor that is peripherally converted to androgens and estrogens in target tissues, and also acts as a GABA receptor antagonist and NMDA receptor agonist. It is approved for the treatment of moderate-to-severe dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is under investigation for various other conditions.
Peso molecular
288,4000 g/mol
LogP
3,20
TPSA
37,30 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Estructura 2D
Cite this structure
Embed this structure
SMILES
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
InChI
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
Molecular Formula
C19H28O2
HBD / HBA
1 / 2
Enlaces Rotables
0
Átomos Pesados
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Prasterone (dehydroepiandrosterone, DHEA) is an endogenous steroid hormone and neurosteroid precursor that is peripherally converted to androgens and estrogens in target tissues, and also acts as a GABA receptor antagonist and NMDA receptor agonist. It is approved for the treatment of moderate-to-severe dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is under investigation for various other conditions.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Prasterone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL90593. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5881. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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