Spectinomycin
Spectinomycin is an aminocyclitol antibiotic with a mechanism similar to aminoglycosides, inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit and interfering with mRNA translocation, used primarily as an alternative treatment for uncomplicated gonorrhea in patients who cannot tolerate cephalosporins or fluoroquinolones. Unlike aminoglycosides, it is not nephrotoxic or ototoxic at therapeutic doses. Its investigational use in stroke is based on potential neuroprotective properties unrelated to its antibiotic activity.
分子量
332.3500 g/mol
LogP
-3.10
TPSA
130.00 Ų
リピンスキーの五則
適合
治療領域
作用機序
Delivers synthetic messenger RNA encoding a specific protein to host cells, where it is translated by ribosomes to produce the therapeutic protein without integrating into the host genome.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Delivers synthetic messenger RNA encoding a specific protein to host cells, where it is translated by ribosomes to produce the therapeutic protein without integrating into the host genome.
2D構造
Cite this structure
Embed this structure
SMILES
CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@@]3(O)C(=O)C[C@@H](C)O[C@H]3O[C@@H]2[C@H]1O
InChI
InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1
Molecular Formula
C14H24N2O7
HBD / HBA
5 / 9
回転可能結合数
2
重原子数
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Spectinomycin is an aminocyclitol antibiotic with a mechanism similar to aminoglycosides, inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit and interfering with mRNA translocation, used primarily as an alternative treatment for uncomplicated gonorrhea in patients who cannot tolerate cephalosporins or fluoroquinolones. Unlike aminoglycosides, it is not nephrotoxic or ototoxic at therapeutic doses. Its investigational use in stroke is based on potential neuroprotective properties unrelated to its antibiotic activity.
Delivers synthetic messenger RNA encoding a specific protein to host cells, where it is translated by ribosomes to produce the therapeutic protein without integrating into the host genome.
Yes, Spectinomycin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1167. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 15541. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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