Tamibarotene
Tamibarotene is a synthetic retinoic acid receptor alpha (RARα) agonist that promotes differentiation of leukemic blast cells, particularly in acute promyelocytic leukemia (APL) and is being studied for other hematologic malignancies. It is more selective for RARα than all-trans retinoic acid (ATRA), with potentially improved efficacy and tolerability in refractory APL. Research has also explored its role in Alzheimer's disease through modulation of neuroinflammatory pathways.
分子量
351.4000 g/mol
LogP
5.40
TPSA
66.40 Ų
リピンスキーの五則
適合
治療領域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21
InChI
InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
Molecular Formula
C22H25NO3
HBD / HBA
2 / 3
回転可能結合数
3
重原子数
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Tamibarotene is a synthetic retinoic acid receptor alpha (RARα) agonist that promotes differentiation of leukemic blast cells, particularly in acute promyelocytic leukemia (APL) and is being studied for other hematologic malignancies. It is more selective for RARα than all-trans retinoic acid (ATRA), with potentially improved efficacy and tolerability in refractory APL. Research has also explored its role in Alzheimer's disease through modulation of neuroinflammatory pathways.
Yes, Tamibarotene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL25202. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 108143. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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