Ubrogepant
Ubrogepant is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) that blocks CGRP-mediated vasodilation and neurogenic inflammation implicated in migraine pathophysiology. It is approved for acute treatment of migraine attacks with or without aura in adults. Unlike triptans, it does not cause vasoconstriction, making it potentially safer for patients with cardiovascular risk factors.
分子量
549.5000 g/mol
LogP
3.10
TPSA
104.00 Ų
リピンスキーの五則
適合
治療領域
作用機序
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D構造
Cite this structure
Embed this structure
SMILES
C[C@@H]1[C@H](c2ccccc2)C[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)N1CC(F)(F)F
InChI
InChI=1S/C29H26F3N5O3/c1-16-20(17-6-3-2-4-7-17)11-22(26(39)37(16)15-29(30,31)32)35-25(38)19-10-18-12-28(13-23(18)34-14-19)21-8-5-9-33-24(21)36-27(28)40/h2-10,14,16,20,22H,11-13,15H2,1H3,(H,35,38)(H,33,36,40)/t16-,20-,22+,28+/m1/s1
Molecular Formula
C29H26F3N5O3
HBD / HBA
2 / 8
回転可能結合数
4
重原子数
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Ubrogepant is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) that blocks CGRP-mediated vasodilation and neurogenic inflammation implicated in migraine pathophysiology. It is approved for acute treatment of migraine attacks with or without aura in adults. Unlike triptans, it does not cause vasoconstriction, making it potentially safer for patients with cardiovascular risk factors.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Ubrogepant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2364638. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 68748835. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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