Ubrogepant
Ubrogepant is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) that blocks CGRP-mediated vasodilation and neurogenic inflammation implicated in migraine pathophysiology. It is approved for acute treatment of migraine attacks with or without aura in adults. Unlike triptans, it does not cause vasoconstriction, making it potentially safer for patients with cardiovascular risk factors.
Khối lượng phân tử
549,5000 g/mol
LogP
3,10
TPSA
104,00 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
C[C@@H]1[C@H](c2ccccc2)C[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)N1CC(F)(F)F
InChI
InChI=1S/C29H26F3N5O3/c1-16-20(17-6-3-2-4-7-17)11-22(26(39)37(16)15-29(30,31)32)35-25(38)19-10-18-12-28(13-23(18)34-14-19)21-8-5-9-33-24(21)36-27(28)40/h2-10,14,16,20,22H,11-13,15H2,1H3,(H,35,38)(H,33,36,40)/t16-,20-,22+,28+/m1/s1
Molecular Formula
C29H26F3N5O3
HBD / HBA
2 / 8
Liên kết có thể quay
4
Nguyên tử nặng
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Ubrogepant is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) that blocks CGRP-mediated vasodilation and neurogenic inflammation implicated in migraine pathophysiology. It is approved for acute treatment of migraine attacks with or without aura in adults. Unlike triptans, it does not cause vasoconstriction, making it potentially safer for patients with cardiovascular risk factors.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Ubrogepant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2364638. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 68748835. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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