Vaborbactam
Vaborbactam is a cyclic boronic acid beta-lactamase inhibitor that covalently and reversibly binds to serine-beta-lactamases, including Klebsiella pneumoniae carbapenemase (KPC) and other class A and C beta-lactamases, restoring the activity of meropenem against carbapenem-resistant organisms. It is used in combination with meropenem (Vabomere) for the treatment of complicated urinary tract infections caused by susceptible gram-negative bacteria. It does not inhibit metallo-beta-lactamases.
分子量
297.1400 g/mol
TPSA
124.00 Ų
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1
InChI
InChI=1S/C12H16BNO5S/c15-11(7-9-2-1-5-20-9)14-10-4-3-8(6-12(16)17)19-13(10)18/h1-2,5,8,10,18H,3-4,6-7H2,(H,14,15)(H,16,17)/t8-,10-/m0/s1
Molecular Formula
C12H16BNO5S
HBD / HBA
3 / 6
回転可能結合数
5
重原子数
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Vaborbactam is a cyclic boronic acid beta-lactamase inhibitor that covalently and reversibly binds to serine-beta-lactamases, including Klebsiella pneumoniae carbapenemase (KPC) and other class A and C beta-lactamases, restoring the activity of meropenem against carbapenem-resistant organisms. It is used in combination with meropenem (Vabomere) for the treatment of complicated urinary tract infections caused by susceptible gram-negative bacteria. It does not inhibit metallo-beta-lactamases.
Yes, Vaborbactam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3317857. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 56649692. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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