Vaborbactam

CHEMBL3317857 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

297.1 g/mol

LogP

—

Phase

4

Vaborbactam is a cyclic boronic acid beta-lactamase inhibitor that covalently and reversibly binds to serine-beta-lactamases, including Klebsiella pneumoniae carbapenemase (KPC) and other class A and C beta-lactamases, restoring the activity of meropenem against carbapenem-resistant organisms. It is used in combination with meropenem (Vabomere) for the treatment of complicated urinary tract infections caused by susceptible gram-negative bacteria. It does not inhibit metallo-beta-lactamases.

Molecular Weight

297.1400 g/mol

TPSA

124.00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1

InChI

InChI=1S/C12H16BNO5S/c15-11(7-9-2-1-5-20-9)14-10-4-3-8(6-12(16)17)19-13(10)18/h1-2,5,8,10,18H,3-4,6-7H2,(H,14,15)(H,16,17)/t8-,10-/m0/s1

Molecular Formula

C12H16BNO5S

HBD / HBA

3 / 6

Rotatable Bonds

5

Heavy Atoms

20

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Vaborbactam is a cyclic boronic acid beta-lactamase inhibitor that covalently and reversibly binds to serine-beta-lactamases, including Klebsiella pneumoniae carbapenemase (KPC) and other class A and C beta-lactamases, restoring the activity of meropenem against carbapenem-resistant organisms. It is used in combination with meropenem (Vabomere) for the treatment of complicated urinary tract infections caused by susceptible gram-negative bacteria. It does not inhibit metallo-beta-lactamases.

Yes, Vaborbactam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3317857. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 56649692. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C12H16BNO5S
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.