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Valsartan

CHEMBL1069 Phase 4 承認済み Small molecule
Half-Life
6 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
435.5 g/mol
LogP
4.4
Phase
4

This angiotensin receptor blocker (ARB) is used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, allowing them to relax and lower blood pressure. Like all ARBs, it should not be taken during pregnancy.

分子量

435.5190 g/mol

LogP

4.40

TPSA

112.00 Ų

リピンスキーの五則

適合

治療領域

Ovarian Cancer Thyroid Cancer Cardiovascular Disease Pain Management Rheumatoid Arthritis Osteoporosis Chronic Obstructive Pulmonary Disease Systemic Lupus Erythematosus Chronic Kidney Disease Stroke Hyperlipidemia Obesity Lymphoma Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain HIV/AIDS Heart Failure Atrial Fibrillation

薬物分類

C — C - Cardiovascular System

作用機序

Angiotensin II type 1 receptor blocker.

Pharmacokinetics (PK)

Half-Life 6 hours

Pharmacodynamics (PD)

機序

Angiotensin II type 1 receptor blocker.

2D構造

SVG PNG

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SMILES

                    
CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H29N5O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
回転可能結合数

                        
10

                    

                    
                    
                    

                        
重原子数

                        
32

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            AGTR1 (Angiotensin II Type 1 Receptor)
                            Antagonist
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            ABCB1 (P-glycoprotein)
                            Substrate
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Minor


                            
                                Valsartan + Digoxin
                            
                        

                        
                        
Valsartan may slightly increase digoxin plasma levels by reducing its renal clearance; the interaction is generally modest.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
This angiotensin receptor blocker (ARB) is used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, allowing them to relax and lower blood pressure. Like all ARBs, it should not be taken during pregnancy.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Angiotensin II type 1 receptor blocker.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Valsartan: Half-life: 6 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Valsartan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Lisinopril
                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1069.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60846.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.