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Valsartan

CHEMBL1069 Phase 4 Approved Small molecule
Half-Life
6 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
435.5 g/mol
LogP
4.4
Phase
4

This angiotensin receptor blocker (ARB) is used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, allowing them to relax and lower blood pressure. Like all ARBs, it should not be taken during pregnancy.

Molecular Weight

435.5190 g/mol

LogP

4.40

TPSA

112.00 Ų

Lipinski RO5

Pass

Therapeutic Areas

Atrial Fibrillation Breast Cancer Cardiovascular Disease Chronic Kidney Disease Chronic Obstructive Pulmonary Disease Chronic Pain Heart Failure HIV/AIDS Hyperlipidemia Hypertension Lymphoma Major Depressive Disorder Obesity Osteoporosis Ovarian Cancer Pain Management Rheumatoid Arthritis Stroke Systemic Lupus Erythematosus Thyroid Cancer Type 2 Diabetes

Drug Classes

C — C - Cardiovascular System

Mechanism of Action

Angiotensin II type 1 receptor blocker.

Pharmacokinetics (PK)

Half-Life 6 hours

Pharmacodynamics (PD)

Mechanism

Angiotensin II type 1 receptor blocker.

2D Structure

SVG PNG

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SMILES

                    
CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H29N5O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
Rotatable Bonds

                        
10

                    

                    
                    
                    

                        
Heavy Atoms

                        
32

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            AGTR1 (Angiotensin II Type 1 Receptor)
                            Antagonist
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            ABCB1 (P-glycoprotein)
                            Substrate
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Minor


                            
                                Valsartan + Digoxin
                            
                        

                        
                        
Valsartan may slightly increase digoxin plasma levels by reducing its renal clearance; the interaction is generally modest.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
This angiotensin receptor blocker (ARB) is used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, allowing them to relax and lower blood pressure. Like all ARBs, it should not be taken during pregnancy.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Angiotensin II type 1 receptor blocker.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Valsartan: Half-life: 6 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Valsartan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Atenolol
                            Small molecule
                        
                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Bisoprolol
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1069.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60846.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.