Cross-Tolerance
A phenomenon in which tolerance developed to one drug confers reduced sensitivity to another drug that acts through the same or a related receptor system or signaling pathway. Cross-tolerance is clinically relevant for drug switching, as patients tolerant to one agent may require higher-than-expected starting doses of a pharmacologically related drug.
例
- Opioid cross-tolerance: morphine tolerance partially extends to hydromorphone and fentanyl
- Benzodiazepine-alcohol cross-tolerance: shared GABA-A receptor potentiation mechanism
- Amphetamine-methylphenidate partial cross-tolerance through dopaminergic pathway overlap
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A phenomenon in which tolerance developed to one drug confers reduced sensitivity to another drug that acts through the same or a related receptor system or signaling pathway. Cross-tolerance is …