Drug-Drug Interaction (DDI)
DDIA change in a drug's effect when administered with another drug. Pharmacokinetic DDIs alter ADME (e.g., CYP inhibition/induction). Pharmacodynamic DDIs alter drug effect (e.g., synergism, antagonism).
例
- Ketoconazole + simvastatin (CYP3A4)
- Warfarin + aspirin (PD)
- Methotrexate + NSAIDs (renal CL)
ご存知でしたか？
A change in a drug's effect when administered with another drug. Pharmacokinetic DDIs alter ADME (e.g., CYP inhibition/induction). Pharmacodynamic DDIs alter drug effect (e.g., synergism, antagonism).