Lead Optimization
The medicinal chemistry process of modifying a lead compound to improve potency, selectivity, ADME properties, and safety while maintaining drug-likeness. Iterative design-make-test-analyze cycles.
例
- Improving metabolic stability
- Reducing hERG liability
- Enhancing oral bioavailability
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The medicinal chemistry process of modifying a lead compound to improve potency, selectivity, ADME properties, and safety while maintaining drug-likeness. Iterative design-make-test-analyze cycles.