Ligand-Gated Ion Channel (LGIC)
LGICIon channels that open or close in response to binding of a specific chemical ligand such as a neurotransmitter. Also called ionotropic receptors, they mediate fast synaptic transmission on the millisecond timescale. Major families include nicotinic acetylcholine, GABA-A, glycine, and glutamate receptors.
例
- GABA-A receptor potentiated by benzodiazepines (anxiety)
- Nicotinic receptor activated by varenicline (smoking cessation)
- NMDA receptor blocked by ketamine (anesthesia/depression)
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Ion channels that open or close in response to binding of a specific chemical ligand such as a neurotransmitter. Also called ionotropic receptors, they mediate fast synaptic transmission on the …