Maintenance Dose
The dose given at regular intervals to maintain steady-state therapeutic concentrations. Equals the amount eliminated per dosing interval. Adjusted for renal/hepatic impairment.
例
- MD = CL * Css * tau / F
- Renal dose adjustment for aminoglycosides
- Hepatic dose adjustment for opioids
ご存知でしたか？
The dose given at regular intervals to maintain steady-state therapeutic concentrations. Equals the amount eliminated per dosing interval. Adjusted for renal/hepatic impairment.