PEPT1 (PEPT1)

Peptide Transporter 1 (gene: SLC15A1), a proton-coupled oligopeptide transporter expressed on the apical membrane of intestinal enterocytes and renal proximal tubule cells. Mediates absorption of di- and tri-peptides from dietary protein digestion and is exploited for oral delivery of peptidomimetic drugs. Recognizes substrates based on peptide bond backbone rather than side chain specificity, enabling broad substrate acceptance.

例

• Valacyclovir (prodrug of acyclovir) oral absorption via PEPT1
• Cephalexin and other aminocephalosporins as PEPT1 substrates
• Valganciclovir prodrug strategy for improved oral bioavailability