Volume of Distribution (Vd)
VdA proportionality constant relating total amount of drug in the body to plasma concentration. A large Vd indicates extensive tissue distribution. Does not correspond to a real physiological volume.
例
- Warfarin Vd ~8L (plasma-bound)
- Chloroquine Vd ~200L/kg (tissue-bound)
- Digoxin Vd ~500L
ご存知でしたか？
A proportionality constant relating total amount of drug in the body to plasma concentration. A large Vd indicates extensive tissue distribution. Does not correspond to a real physiological volume.